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KMID : 0604520160420010009
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Journal of the Society of Cosmetic Scientists of Korea
2016 Volume.42 No. 1 p.9 ~ p.13
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A Study of Stabilization for Insoluble Active Ingredients Using Swollen Micelles
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Kim Su-Ji
Jung You-Lee
Nam Jin-Ju
Jang Ji-Hui
Yeo Hye-Lim
Yoon Moung-Seok
Yoo Kweon-Jong
Lee Jun-Bae
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Abstract
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Micelles, which are called solubilization formulation, have been widely used in skin lotion, mist or various formulations for the purpose of solubilizing the fragrance rather than the role of the active ingredient carrier because the particles are very small. In this study, we developed the swollen micelle having a transparent appearance to deliver β-sitosterol. When preparing the swollen micelle, solubility parameter was considered with active ingredient. This method allowed insoluble active ingredient to be safely entrapped inside the micelles. Stability of micelle was evaluated by dynamic light scattering (DLS). The transparency and shape of the micelles were confirmed by cryo-TEM. In addition, through the thermal analysis using DSC, β-sitosterol was found to be stably present in the swollen micelles. These results indicate that swollen micelles considered solubility parameter could be used as a new carrier for the insoluble active ingredients.
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KEYWORD
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solubilization, solubility parameter, swollen micelle, β-sitosterol
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